Clofilium tosylate
CAS No. 92953-10-1
Clofilium tosylate ( —— )
Catalog No. M26654 CAS No. 92953-10-1
Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 27 | Get Quote |
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5MG | 43 | Get Quote |
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10MG | 72 | Get Quote |
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25MG | 152 | Get Quote |
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50MG | 284 | Get Quote |
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100MG | 424 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameClofilium tosylate
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NoteResearch use only, not for human use.
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Brief DescriptionClofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.
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DescriptionClofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.(In Vitro):Treatment with 0-20 μM Clofilium inhibits viability and proliferation in a time- and concentration-dependent manner in HL-60 cells. Cell viability is significantly reduced in HL-60 cells treated with 2.5 μM to 10 μM Clofilium After 12 hours. Treatment with 10 μM Clofilium induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP. However, the expression of Bcl-2 and Bax proteins does not change significantly.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number92953-10-1
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Formula Weight510.2
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Molecular FormulaC28H44ClNO3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1ccc(cc1)S([O-])(=O)=O.CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nabavi SF, et al. Neuroprotective effects of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in the brain of rats. Cell Mol Neurobiol. 2013 Mar;33(2):261-7.
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